Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Genetic Tests and Reporting By Included Studies a

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Medications

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Primary Study Baseline Characteristics

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Change in HAM-D17 Depression Scores at Final Follow-Up

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Change in Depression Scores on Alternative Depression Scales at Final Follow-Up

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Results of Change in HAM-D17 Depression Scores With Less Than 8-Week Follow-Up

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: GRADE Evidence Profile for Comparison of GeneSight-Guided Treatment Selection With Treatment as Usual—Change in Depression Score

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Comparison, Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Change in Depression Scores on Alternative Depression Scales (< 8-Week Follow-Up)

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Change in Depression Scores—Sub-population Analyses by Genetic Test Interpretive Report Classification for Baseline Medications

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Risk Difference in Response for Pharmacogenomic-Guided Medication Selection Compared With Treatment as Usual Based on HAM-D17

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Relative Risk of Response for Pharmacogenomic-Guided Medication Selection Compared With Treatment as Usual Based on Alternative Depression Scales

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Relative Risk of Remission for PGx Compared With TAU Based on QIDS-C16, PHQ-9, and HAM-D6 Scales

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Treatment Selection Based on Genetic Test Classification for PGx Versus TAU

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection, Medications

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Results of Economic Literature Review—Summary

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Intervention and Comparator Evaluated in Primary Economic Model: Reference Case Analysis

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: GRADE Evidence Profile for Comparison of GeneSight-Guided Treatment Selection With Treatment as Usual—Remission

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Comparison, Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Other Parameter-Specific Sensitivity Analyses: Remission, Relapse, Disutilities, and Costs

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: GRADE Evidence Profile for Comparison of GeneSight-Guided Treatment Selection and Treatment as Usual—Response

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Comparison, Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Guidelines and Health Technology Assessment Recommendations on Use of Pharmacogenomic Testing for Guiding Treatment Among People With Depression

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Characteristics of Identified Systematic Reviews

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Functional Assay

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Summary of Study Design and Characteristics of Included Studies

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Risk Difference in Response for Pharmacogenomic-Guided Medication Selection Compared With Treatment as Usual Based on HAM-D17

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Relative Risk of Response for Pharmacogenomic-Guided Medication Selection Compared With Treatment as Usual Based on Alternative Depression Scales

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Response Rates for Pharmacogenomic-Guided Medication Selection Compared With Treatment as Usual—Post-Hoc Stratifications and Subgroup Analyses by Baseline Characteristics

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Risk Difference in Remission for Pharmacogenomic-Guided Medication Selection Compared With Treatment as Usual Based on HAM-D17

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Remission Rates for Pharmacogenomic-Guided Medication Selection Compared With Treatment as Usual—Post-Hoc Stratifications and Subgroup Analyses by Baseline Characteristics

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Applicability of Studies Evaluating Cost-Effectiveness of Multi-gene Pharmacogenomic-Guided Treatment Versus Treatment as Usual in People With Major Depression

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Limitations of Studies Evaluating Cost-Effectiveness of Multi-gene Pharmacogenomic-Guided Treatment Versus Treatment as Usual in People With Major Depression

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Intervention and Comparator Evaluated in Primary Economic Model: Reference Case Analysis

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Multi-gene Pharmacogenomic Tests Considered

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Effectiveness of Multi-gene Pharmacogenomic-Guided Treatment

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Costs and Resource Use Inputs in Economic Model

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Costs and Resource Use Inputs in Economic Model, Additional Information

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Target Population for Multi-gene Pharmacogenomic Testing in Ontario

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Volume After Accounting for Uptake of Multi-gene Pharmacogenomic Testing in Ontario During Years 1 to 5

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Scenario 5: Extending Coverage to Young Adults (OHIP+ Scenario)

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Scenario 5: OHIP+ Volume, Accounting for Uptake of Multi-gene Pharmacogenomic Testing in Ontario, Years 1 to 5

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Budget Impact Analysis of Reference Case Results for Multi-gene Pharmacogenomic Testing in Ontario

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Budget Impact in Sensitivity Analysis

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet:

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: GRADE Evidence Profile for Comparison of Treatment Guided by Unspecified Pharmacogenomic Test With Treatment as Usual—Change in Depression Score

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: GRADE Evidence Profile for Comparison of Unspecified Pharmacogenomic-Guided Treatment Selection and Treatment as Usual—Response

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: GRADE Evidence Profile for Comparison of Unspecified Pharmacogenomic-Guided Treatment Selection and Treatment as Usual—Remission

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: GRADE Evidence Profile for Comparison of Pharmacogenomic-Guided Treatment Selection With Treatment as Usual—Side Effects and Adverse Events

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: Selection

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet:

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Article Snippet: Table 10: Clinicaltrials.gov Identifier Title Genetic Test Evaluated {"type":"clinical-trial","attrs":{"text":"NCT02466477","term_id":"NCT02466477"}} NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight {"type":"clinical-trial","attrs":{"text":"NCT03749629","term_id":"NCT03749629"}} NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight {"type":"clinical-trial","attrs":{"text":"NCT03952494","term_id":"NCT03952494"}} NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express {"type":"clinical-trial","attrs":{"text":"NCT03591224","term_id":"NCT03591224"}} NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck {"type":"clinical-trial","attrs":{"text":"NCT03468309","term_id":"NCT03468309"}} NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques:

Journal: Ontario Health Technology Assessment Series

Article Title: Multi-gene Pharmacogenomic Testing That Includes Decision-Support Tools to Guide Medication Selection for Major Depression: A Health Technology Assessment

doi:

Figure Lengend Snippet: Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Article Snippet: Ongoing Studies We are aware of the following ongoing or recently completed (not yet published) studies that have potential relevance to this review. table ft1 table-wrap mode="anchored" t5 Table 10: caption a7 Clinicaltrials.gov Identifier Title Genetic Test Evaluated {"type":"clinical-trial","attrs":{"text":"NCT02466477","term_id":"NCT02466477"}} NCT02466477 Pharmacogenomic Decision Support With GeneSight Psychotropic to Guide the Treatment of Major Depressive Disorder GeneSight {"type":"clinical-trial","attrs":{"text":"NCT03749629","term_id":"NCT03749629"}} NCT03749629 Comparative Effectiveness of Pharmacogenomics for Treatment of Depression (CEPIO-D) GeneSight {"type":"clinical-trial","attrs":{"text":"NCT03952494","term_id":"NCT03952494"}} NCT03952494 Individualizing Antidepressant Treatment Using Pharmacogenomics and EHR-driven Clinical Decision Support (MyGenes) Genomind Professional PGx Express {"type":"clinical-trial","attrs":{"text":"NCT03591224","term_id":"NCT03591224"}} NCT03591224 Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy Pillcheck {"type":"clinical-trial","attrs":{"text":"NCT03468309","term_id":"NCT03468309"}} NCT03468309 Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT) Genecept Assay and G-DIG decision tool Open in a separate window Ongoing or Recently Completed Comparative Studies on Multi-gene Pharmacogenomic Testing

Techniques: